Akkermansia Muciniphila Postbiotics

【Name】

Main Ingredients： Akkermansia muciniphila AK47, maltodextrin

【Potency】

【Source】

This strain was isolated from healthy human feces

【Storage and shelf life】

The pasteurized Akk probiotics can be stored in a cool and dry place, the shelf life is 24 months.

【Packaging】

Akkermansia Muciniphila Postbiotics's inner bag is a PE self-sealing bag, and the outer layer is a high-barrier aluminum foil bag with heat sealing. According to customer requirements, the packaging specifications are divided into 500g/bag, 1kg/bag, and 5kg/bag.

【Safety and Quality】

GMP standards manufacture the freeze-dried probiotic powder and obey the relevant laws, rules, and regulations in China.

【Non-GMO】

No genetic engineering, mutagenesis, or gene manipulation has ever been performed on this strain. To the best of our knowledge, this product is not derived from or produced using GMOs or their derivatives, and all reasonable steps have been taken to avoid contamination from GMOs or their derivatives.

Akkermansia probiotics Functionality

Prevent atherosclerosis

①Alleviate endothelial cell injury

Endothelial dysfunction is an important risk factor for cardiovascular diseases and is the initial step in the pathogenesis of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) is one of the important factors causing endothelial cell injury and is involved in cell damage as well as the occurrence and development of atherosclerotic lesions. In this experiment, an ox-LDL-induced HAEC cell (human aortic endothelial cell) injury model was used to determine the effects of different doses of inactivated AK47 (low dose 10⁵ cells/mL, high dose 10⁶ cells/mL) on HAEC cell viability, lactate dehydrogenase (LDH) release, and reactive oxygen species (ROS) levels. The experimental results are shown in the figure below:

The results indicated that the application of Akkermansia probiotics, in varying concentrations, did not exert a notably detrimental influence on cell viability.

Endothelial cell dysfunction, apoptosis, or necrosis that leads to the destruction of cell membrane structure can result in the release of lactate dehydrogenase (LDH) from the cytoplasm into the culture medium. Therefore, LDH release is considered an important indicator for detecting cell integrity. The experimental results showed that after treatment with ox-LDL for 24 hours, the LDH release from HAEC cells was significantly enhanced compared to the control group. However, treatment with different doses of AK47 significantly reversed the increase in intracellular LDH release induced by oxidized low-density lipoprotein, indicating that HH-AKK1 has a protective effect on cell membrane structure and can inhibit the outflow of intracellular substances.

Reactive Oxygen Species (ROS) are crucial indicators of cellular oxidative damage and are associated with a variety of cardiovascular diseases. The experiment demonstrated that compared to the control group cells, the level of ROS within HAEC cells was significantly increased after stimulation with ox-LDL. However, treatment with different doses of AK47 significantly reduced the cellular ROS content, indicating that it can alleviate cellular oxidative damage.

②Modulate lipid metabolism

In this experiment, an obesity model was established in ApoE gene knockout (ApoE^-/-) mice by inducing obesity with a high-fat diet. The control group and the model group were gavaged with a glycerin preparation without AK47, while the AKK intervention group was gavaged with a glycerin preparation containing 1×10⁹ cells of AK47. Gavage was performed once daily at a dose of 0.1 mL for 4 weeks. The effects of Akkermansia muciniphila on blood lipid metabolism-related indicators (TG, TC, HDL-C, LDL-C) were observed. The experimental results are shown in the table below. The blood lipid metabolism indicators TG, TC, and LDL-C in the HH-AKK1 intervention group were significantly lower than those in the model group, and TG and LDL-C were significantly lower than those in the control group, indicating that Akk probiotics can reverse the lipid metabolism abnormalities caused by a high-fat diet.

Table 1. Blood lipid metabolism-related indicators

③Modulate inflammation cytokines

The effects of Akkermansia Muciniphila Postbiotics on inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, C-reactive protein, TNF-α, and monocyte chemoattractant protein-1 (MCP-1)) were observed in the above obesity mice model. The experimental results are shown in the table below. The inflammatory cytokines IL-1, IL-6, IL-8, CRP, TNF-α, and MCP-1 in the HH-AKK1 intervention group were significantly lower than those in the model group and the control group, indicating that it can reduce the levels of serum inflammatory factors in obese mice.

Table 2. Inflammation cytokines in different mice groups

Application

Pasteurized Akkermansia muciniphila AK47 freeze-dried powder can be widely used in food, dietary supplements, and medicine.

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