Patent glory | The functional strain Lactobacillus johnsonii LBJ456 has been granted a Chinese invention patent, with unique advantages in inhibiting tumor cell reproduction
A 15-year scientific evidence-based journey: opening up new avenues for anti-cancer treatment
Faced with these challenges, the researchers at the Hehe Science and Technology Innovation Center have been looking for new treatments to improve treatment efficacy, reduce side effects and lower treatment costs. In this context, Hehe's patented strain, Lactobacillus johnsonii bacteria LBJ456, with its unique anti-inflammatory and anti-cancer properties, provides new ideas and hope for cancer treatment.
Research history: 2010-2024
The impact of intestinal flora on immunity and inflammatory response
Related research on the relationship between intestinal flora and radiation protection
Related research on LBJ456® anti-inflammatory and anti-cancer
LBJ456® genome information is stored in the National Center for Bioinformation (NCBI) database
LBJ456® is preserved by Hehe Bio in the China Center for Type Culture Collection (CCTCC)
The series of studies were funded by the US NIH and NASA
Research results
2 US invention patents
1 EU invention patent
1 Chinese invention patent
7 related academic papers published
Characteristics of lactobacillus johnsonii probiotic
Gastric acid and bile salt tolerance: It can survive under extremely acidic conditions (pH 1.2). It also has outstanding tolerance in 0.3% bile salts.
Long-term colonization: In human experiments, the colonization time can reach 60 days.
Anti-cancer mechanism
Lactobacillus johnsonii products LBJ456 has been proven to have significant anti-inflammatory effects in animal experiments. It can reduce the levels of pro-inflammatory cytokines in the blood of mice and induce the body to produce anti-inflammatory factors. By reducing the occurrence of systemic inflammation, it reduces Genotoxicity, thereby preventing cancer.
By inhibiting common pathogenic bacteria such as Salmonella, Escherichia coli, and Enterococcus faecalis, Lactobacillus johnsonii supplement reduces the activity of carcinogen synthetases produced by these pathogenic bacteria, such as achloride reductase, glucuronidase, nitrate reductase, etc. This can achieve the effect of reducing the production of carcinogens, extending life expectancy, and delaying the onset of cancer. It is suitable for a variety of p53-deficient cancers and provides new strategies for cancer prevention and treatment.
lactobacillus johnsonii benefits : All-round protection
Lactobacillus johnsonii LBJ456® has a wide range of application scenarios, including:
Assisting surgical therapy to enhance body resistance
Combined chemotherapy treatment to relieve intestinal discomfort caused by chemotherapy
Supportive treatment during radiotherapy to relieve intestinal inflammation
A partner for targeted therapy to improve treatment effects
Synergistic effects of immunotherapy to enhance immune response
Maintenance treatment during cancer recovery to restore intestinal health
Prevent cancer recurrence and reduce the risk of recurrence
Comfort care in palliative care to improve quality of life
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