Probioway Co., Ltd. is one of the leading manufacturers and suppliers of lactobacillus johnsonii in China, also supports custom service. Please feel free to wholesale bulk high quality lactobacillus johnsonii from our factory. Good service and reasonable price are available.
Introduction
Lactobacillus johnsonii LBJ456 is a Gram-positive, non-spore-forming anaerobic bacterium that belongs to the Lactobacillus genus. It is widely found in the human gut and plays an important role in maintaining gastrointestinal health. Lactobacillus johnsonii LBJ456 is a novel strain that has been isolated and characterized in recent years.
Lactobacillus johnsonii LBJ456 has several unique characteristics that distinguish it from other strains of lactobacilli. It has strong acid-producing ability and can survive in low pH environments. It also has good tolerance to bile salts and can survive in the presence of high concentrations of bile.
INGREDIENTS :Lactobacillus johnsonii LBJ 456 and Carrier
PRODUCT STANDARD :1.0E+11 CFU/g (100billion CFU/g), 2.0E+11 CFU/g (200billion CFU/g)
APPLICATIONS :Dietary supplements; Functional foods (Beverages, Dairies etc.)
APPEARANCE :Off-white or light yellow powder
Patents: (NO.: WO2014130540), one in
Europe(NO.: EP2958575A1), two in USA(NO.: US10413577B2 and US10028983B2).
TECHNICAL INDICATORS
PACKAGE
1kg/Aluminum foil bag
STORAGE and SHELF LIFE
Storage at well closed condition, suggested under -18°C for longtime storage, 2~8°C in cooling, The shelf life is 24 months.
Functions:
Lactobacillus johnsonii strain LBJ 456TM has been shown in animal experiments to reduce systemic inflammation by reducing the levels of proinflammatory cytokines IL-1β and IFN-β in the host, while increasing the levels of anti-inflammatory cytokines TGFβ and IL-10 The occurrence of serotonin can further reduce genotoxicity and achieve the effect of preventing and treating cancer.
MECHANISM
- Eliminate inflammation caused by pathogenic bacteria
- Reduce chronic inflammation
- Reduce oxidative stress
Reduce genotoxicity (DNA deletion, breakage, damage)
Reduce cancer incidence,Postpone the onset of cancer,Prolong life,Radio protection
BENEFITS FROM TRIAL
+ Eliminate and reduce inflammation
The levels of cytokines in liver tissues of mice were detected by ELISA. Compared with controls, the levels of proinflammatory cytokines IL-1β and IFN-γ in mice in the experimental group after taking Lactobacillus johnsonii LBJ 456TM decreased, while anti-inflammatory cells Increased levels of factor TGF-β and IL-10.
ELISA method was used to detect the level of cytokines in the blood of mice. Compared with the control, the level of proinflammatory cytokine IFN-γ in the experimental group was significantly reduced after taking Lactobacillus johnsonii LBJ 456TM.
The flow cytometer was used to detect Hepatic NK cells in the liver of mice, and it was found that the content of mice taking Lactobacillus johnsonii LBJ 456TM was much lower than that of the control group. Studies have shown that natural killer cells in the liver may directly damage host cells, causing local or systemic inflammation.
Therefore, Lactobacillus johnsonii LBJ 456TM can reduce inflammation by reducing the number of natural killer cells in the liver.
+ Reduce cancer incidence and Postpone the onset of cancer,Prolong life
By detecting the ratio of GSH / GSSG in the peripheral blood of mice, it can be found that the RM group of mice rich in Lactobacillus johnsonii LBJ 456TM has a lower level of oxidative stress than the control group (CM). Studies have shown that the level of oxidative stress is closely related to genotoxicity and carcinogenesis. Therefore, by regulating the level of oxidative stress, it can play a role in preventing cancer
Carrying on the feeding experiment of the tested mice for 4 weeks, it was found that the genetic damage of the mice taken was reduced by more than 40% compared with the control group, indicating that it can reduce the genotoxicity well and thus play an anti-cancer effect
By detecting the micronucleus level of bone marrow erythrocytes in mice, it can be found that the RM group of mice rich in Lactobacillus johnsonii LBJ 456TM has lower chromosomal damage and genotoxicity than the control group (CM), so the carcinogenic rate is lower.
By detecting the micronucleus level of bone marrow erythrocytes in mice, it can be found that the RM group of mice rich in Lactobacillus johnsonii LBJ 456TM has lower chromosomal damage and genotoxicity than the control group (CM), so the carcinogenic rate is lower. After Kaplan-Meier survival analysis, the survival period of 50% of mice increased from 31.3 weeks to 45.6 weeks, and the life span was greatly extended
Hot Tags: lactobacillus johnsonii, manufacturers, factory, custom, wholesale, bulk, lb rhamnosus, lactobacillus rhamnosus supplement, lactobacillus rhamnosus plus, bacteria rhamnosus, probiotyk rhamnosus, le lactobacillus rhamnosus
