Stress Release Probiotics
Specifications: 0.5 g×60 capsules/box
Formula (content per capsule):
Lactobacillus plantarum N-1: 12 Billion CFU
Lactobacillus acidophilus HH-LA26: 8 Billion CFU
Bifidobacterium longum HH-BL18: 10 Billion CFU
Theanine, chamomile, lemon balm, passionflower, galactooligosaccharide, stachyose, VB12, VB6
The Stress Release Probiotics are a custom blend of probiotics designed to relieve stress. This probiotic formula contains the patented and scientifically proven probiotic strain Lactobacillus plantarum N-1, which is scientifically proven to:
√Relieve stress
√ Improve autism
Recommended dosage: Take one tablet daily for at least two weeks.
Lack of "happiness factor" causes emotional problems
Several studies have shown that emotional management and sleep problems are closely related to the dysfunction of the brain's reward circuit, which in turn leads to a decrease in dopamine secretion. In addition to dopamine, many substances in the brain also play an important role in regulating emotions, such as serotonin. (5-hydroxytryptamine), oxytocin and endorphins, etc.; 50% of dopamine and 95% of 5-hydroxytryptamine in the human body are produced in the intestines.
The mechanism by which intestinal flora affects mental health
According to research on the gut-brain axis mechanism in the past decade, scientists have found that intestinal flora can affect mental health through the following three main ways:
1. Directly affects emotions and cognitive processes through changes in the diversity and abundance of bacterial flora;
2. When under stress or in a stressful environment, it affects the stress secretion and inflammatory response of glucocorticoid through the hypothalamic-pituitary-adrenal axis (HPA axis);
3. Neurotransmitters are produced through special fiber metabolism, and these neurotransmitters may be involved in regulating the synaptic activity of neurons near the enteric nervous system.
Mechanism of action of probiotics
After food rich in probiotics enters the intestine, it produces secondary metabolites (such as short-chain fatty acids), immune signals, neurotransmitters (such as dopamine, 5-hydroxytryptamine), etc., which can pass through the "bacteria-gut-brain axis" Two-way communication with the brain.
Mood probiotics may represent a breakthrough in nutritional psychiatry, offering safe, low-cost, and less invasive treatments than some traditional treatments for mental illness.
Compared with drugs, consumers prefer probiotic foods from natural sources to solve their sleep and mood problems.
Lactobacillus plantarum N-1[2]
Source of bacteria: Yak cheese from the Qinghai-Tibet Plateau
Collection number: CGMCC No.15463
Acid and bile salt tolerance[3]
Acid and bile tolerance are the most important properties of probiotics as they determine their ability to survive in the small intestine and thus exert their functional role as a probiotic. N-1 showed very good survival at low pH and high bile salt concentration.
Adhesion[4]
The ability to adhere to the host is an important criterion for screening potential probiotics. It is thought to be associated with colonization, pathogen suppression, immune interactions, and enhancement of barrier function. The adhesion test results showed that the adhesion number of N-1 to Caco-2 cells was 6.04×106 CFU/mL, and the adhesion rate was 4.03%.
Note: The Caco-2 cell model is a human cloned colon adenocarcinoma cell. Its structure and function are similar to differentiated small intestinal epithelial cells. It has structures such as microvilli and contains enzyme systems related to the brush border epithelium of the small intestine. It can be used to Perform experiments simulating intestinal transport in vivo.
Dopamine regulation function verification
Analysis of dopamine concentration in the brains of mice using lactic acid strains to prevent melancholia in mice.
The concentration of dopamine in the brains of mice in the daily probiotic group reached a statistical difference, which increased by 27% compared with the disease-causing group, and the effect was significant.
Validation of serotonin regulatory function
In a mouse trial using lactic acid strains to prevent melancholia, the concentration of serotonin in the brains of mice was analyzed:
The concentration of the probiotic group can reach 21 ng/mg, which is a 90% increase compared to the 11 ng of the disease group. It is a very significant improvement and reaches a statistical difference (P < 0.01).
Stress relief function[1]
N-1 can significantly improve anxiety, stress, depression-like and other behaviors in autistic mice
N-1 can improve the structure of intestinal flora, significantly increase the abundance of beneficial bacteria such as Allobaculum and Oscillospira, and reduce harmful bacteria such as Sutterella
Note: Open field experiment: observe the autonomous behavior, exploratory behavior, and tension of experimental animals in novel environments.
Raw materials from the same origin as medicine and food:
Theanine: Theanine is one of the important elements in the process of people cultivating their bodies and strengthening their bodies. It has very powerful physiological healthcare functions, such as relieving people's fatigue, lowering blood pressure, improving people's memory, etc. Theanine can effectively promote the release of dopamine in the human brain center, thereby improving its physiological activity.
Chamomile: German Chamomile (German Chamomile) is native to Europe and belongs to the genus Matricaria of the Asteraceae family. It is an overwintering annual herb. The inflorescence has a light apple fragrance and has the effects of improving sleep, calming mood, nourishing the liver, and lowering blood pressure.
Lemon balm: In pharmacopeia and traditional medicine, lemon balm is used to treat gastrointestinal diseases and as a sedative to treat sleep disorders; in folk medicine, it is used to treat coughs, dizziness, dysmenorrhea, skin infections, and as a sedative, Antispasmodic, antiseptic.
Passionflower: Passionflower extract enhances affinity for GABA receptors and inhibits GABA reuptake in rat cortical synaptosomes; induces direct GABA currents in CA1 hippocampal pyramidal neurons, similar to benzodiazepines effects of drugs.
Articles & Patents
[1] Qiu Z, et al. (2023) Lactiplantibacillus plantarum N-1 improves autism-like behavior and gut microbiota in mice. Frontiers in Microbiology. DOI 10.3389/fmicb.2023.1134517
[2] Liu Y, et al. (2021) Lactiplantibacillus plantarum Reduced Renal Calcium Oxalate Stones by Regulating Arginine Metabolism in Gut Microbiota. Front. Microbiol. 12:743097.
[3] Wei Z, et al. Probiotic Lactiplantibacillus plantarum N-1 could prevent ethylene glycol-induced kidney stones by regulating gut microbiota and enhancing intestinal barrier function. FASEB J. 2021:35(11):e21937.
[4] Tian L, et al. Probiotic Characteristics of Lactiplantibacillus plantarum N-1 and Its Cholesterol-Lowering Effect in Hypercholesterolemic Rats. Probiotics Antimicrob Proteins. 2022; 14 (2): 337-348.
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