What's the benefits of AKK probiotics?
Nature published a review on Akkermansia muciniphila, referring to 150 articles. It brought together major research and clinical projects in which AKK bacteria were applied, proving that maintaining the abundance of akkermansia probiotic is associated with obesity, diabetes, hepatic steatosis, inflammation (colitis), and response to cancer immunotherapy; and that it regulates the synthesis of neurotransmitters and receptor expression through the gut-brain axis, affects emotions, cognition, and circadian rhythms, and has a good effect on improving amyotrophic lateral sclerosis, insomnia, depression, and anxiety.
probiotic akkermansia delay aging through multi-purpose anti-inflammation. Aging is a condition in which the intestinal barrier is reduced and inflammation is increased. AKK bacteria enhance immunity, resist and suppress inflammation by improving the host intestinal barrier and intestinal flora homeostasis; at the same time, they secrete specificity Proteins Amuc_1100 and P9 can produce short-chain fatty acids with multi-functional anti-inflammatory effects, regulate GLP-1 receptors, resist sugar and inflammation, and delay aging.
Akkermansia probiotics - intestinal barrier - multi-effect anti-inflammatory and anti-aging Amuc_1100--TRL2--5-TH--microbial balance anti-inflammatory Amuc_1100 increases T cells and reduces visceral fat inflammation Amuc_1100--increases mucus--strengthens the barrier and anti-inflammatory, downregulates pro-inflammatory factors TNF-α, IL-6, IL-1α and IL-12A P9 protein--GLP1/short-chain fatty acids--reduces inflammation.
AKK bacteria improves colitis through NLRP3 and T cells. 70%-80% of the human immune cells are in the intestines, such as T cells, B cells, NK cells, etc., which are concentrated in the intestinal mucosa; NLRP3 is a cytoplasmic immune regulator and a major component of the innate immune system. Administration of AKK bacteria can reduce the levels of inflammatory cytokines in serum and colon tissue, enhance barrier function, and improve inflammatory bowel disease (IBD).
AKK probiotic fights sugar and loses weight through specific protein P9. Cell reported that intestinal flora can promote insulin secretion, and the P9 protein secreted by AKK bacteria can stimulate GLP-1 receptors to regulate insulin levels and stabilize blood sugar; delay gastric emptying, achieve weight loss through central appetite suppression, and reduce the risk of type 2 diabetes.
AKKermansia probiotics is a "probiotic" with anti-tumor effects. Science published that specific intestinal bacteria improve immunotherapy. Patients with poor immunotherapy effects lack AKK bacteria in their bodies. Akk bacteria can be used to regulate and restore the intestinal flora of patients through intestinal bacteria transplantation, which can greatly enhance the effect of immunotherapy.
AKK bacteria regulate the gut-brain axis to affect brain function and host behavior.
There is a gut-brain axis between the gut and the brain, and the gut flora can communicate through the interaction of the nervous, immune and endocrine systems. AKK bacteria are beneficial intestinal bacteria that regulate neural responses by producing short-chain fatty acids and directly or indirectly regulate the gut-brain axis by acting on immune pathways. For example, it improves metabolic diseases, mental illnesses, and neurodegenerative diseases caused by intestinal flora imbalance.
Maintaining the abundance of AKKermansia probiotics can reduce the risk of depression. AKK bacteria can help people with depression and anxiety through neurotransmitters. The specific protein Amuc_1100 can increase the content of 5-HT in the hippocampus. Relieve negative emotions such as depression and pessimism, enhance emotional stability, and improve the common emotional sleep disorders in this group of people. There is a two-way relationship between sleep quality and intestinal flora composition. AKK bacteria regulate sleep hormones such as serotonin (5-HT), dopamine, γ-aminobutyric acid (GABA), SCFAs and melatonin through the gut-brain axis.