Probioway Co., Ltd. is one of the leading manufacturers and suppliers of reduce cancer incidence probiotics in China, also supports custom service. Please feel free to wholesale bulk high quality reduce cancer incidence probiotics from our factory. Good service and reasonable price are available.
Specifications: 0.5 g×60 capsules/box
Formula (content per capsule):
Lactobacillus johnsonii LBJ456®: 12 Billion CFU
Lactobacillus acidophilus HH-LA26: 8 Billion CFU
Bifidobacterium lactis HH-BA68: 10 Billion CFU
Cranberry, acerola, mulberry fruit powder, galactooligosaccharides, inulin
This probiotic formula is a probiotic formula customized to fight cancer. This probiotic formula contains the patented and scientifically proven probiotic strain Lactobacillus johnsonii LBJ456®, which is scientifically proven to:
√ Strong adhesion and colonization ability
√ Excellent anti-inflammatory effect
Recommended dosage: Take one tablet daily for at least two weeks.
Cancer is a general term for a large class of malignant tumors
Cancer cells are characterized by unrestricted and endless proliferation, which consumes a large amount of nutrients in the patient's body;
Cancer cells release a variety of toxins, causing a series of symptoms in the human body;
Cancer cells can also metastasize, grow, and multiply throughout the body.
cancer cell metastasis
Under certain circumstances, cancer cells will leave the original focus, spread to further parts of the body through the blood or lymphatic system, and form new tumors in other parts of the body. This process is called metastasis; the metastasis of cancer cells leads to weight loss and weakness in the body. , anemia, loss of appetite, fever, severe damage to organ function, etc.
Current status and trends of cancer in the United States[1]
It is estimated that 609,820 people will die from cancer in the United States in 2023, which is equivalent to 1,670 deaths every day.
Among men, the most common causes of death are lung, prostate, and colorectal cancers;
Among women, the largest number of deaths are from lung, breast, and colorectal cancers.
Graphic: Estimated number of deaths and major cancer types by gender in the United States in 2023
Gut flora and cancer
The 10 trillion bacteria in the intestines form a small chemical factory, in which harmful bacteria will decompose digested food and other substances in the body into many carcinogens, the most common of which are nitrosamines, indoles, phenols, secondary bile acid.
Probiotic anti-tumor mode of action
① Degrade or adsorb carcinogens, thereby reducing their toxicity;
② Stimulate the human immune system and resist the proliferation of cancer cells; inhibit the growth of putrefactive bacteria in the intestines by improving the intestinal environment, thereby preventing the formation of carcinogens in the intestines;
③ Produce compounds that inhibit the growth of tumor cells or metabolites that kill harmful bacteria.
Anti-tumor mechanism of probiotics[2]
Probiotics have the ability to modulate cancer signaling pathways,
Probiotics can pass
(a) Inducing apoptosis,
(b) Inhibit mutagenic activity,
(c) Downregulate oncogene expression,
(d) Inducing autophagy,
(e) Inhibit kinases,
(f) Reactivation of tumor suppressors,
(g) Modulate cancer by preventing metastasis.
Illustration: Schematic diagram of the mechanism of using probiotics to prevent or treat cancer.
Lactobacillus johnsonii LBJ456®
Source of strain: healthy mouse intestine
Collection number: CCTCC No: M20191013
Patent publication number: CN111534467A
U.S. Patent Number: US 10,028,983 B2
Gastric acid tolerance[3]
Gastric acid tolerance is the most important property of probiotics as it determines their ability to survive in the small intestine and thus exert their functional role as a probiotic. When the pH finally reached 1.2, although the number of Lactobacillus johnsonii dropped by 3 orders of magnitude, it was the only surviving strain in the experiment. Therefore, extremely strong gastric acid tolerance is an important basis for its successful adherent colonization.
adhesion
The ability to adhere to the host is an important criterion for screening potential probiotics. It is thought to be associated with colonization, pathogen suppression, immune interactions, and enhancement of barrier function. In an in vitro monolayer cell adhesion experiment using LS174T cells, the adhesion effect of Lactobacillus johnsonii LBJ456 was higher than that of Lactobacillus acidophilus, Lactobacillus plantarum 299V and Bifidobacterium lactis HN019.
Anti-cancer function verification
The researchers retrospectively evaluated 118 patients with advanced lung cancer who received immunotherapy and analyzed stool samples from 80 patients with lung cancer. Among the 118 patients included, 72 were PPI users (35% of whom used probiotics) and 46 were non-users of PPIs (30% of whom used probiotics).
a) PPI group
b) PPI + probiotic control group
c) PPI+antibiotics+probiotics control group
Through statistical analysis, it was found that:
a) The overall survival of patients who used PPIs was significantly shortened. The analysis found that this negative effect of PPIs was more obvious in patients who did not use probiotics and used antibiotics.
b) Among patients using PPIs, the progression-free survival (PFS) of patients using probiotics was significantly prolonged, with a median PFS of 250 days vs. 88 days.
c) Among patients using PPI + antibiotics, the progression-free survival (PFS) of patients using probiotics was also significantly longer than that of patients who did not use probiotics.
It can be seen that the negative impact of two ineffective induction immunotherapy drugs (PPI and antibiotics) on the efficacy of ICB can be reduced by using combined probiotics.
Remark:
PPI: A common gastric mucosal protective agent, PPI can cause microorganisms in the oral cavity to transfer to the intestine, thereby negatively affecting the efficacy of immunotherapy in cancer patients.
PFS: refers to the period between the start of treatment and the observation of disease progression or death from any cause.
Raw materials from the same origin as medicine and food:
Cranberry: The physiologically active substances in cranberries can resist lipid peroxidation of unsaturated fatty acids in biofilms, protect the structure and function of biofilms, and prevent various degenerative diseases; they can prevent urinary tract infections and resist Helicobacter pylori. , antioxidant, anti-tumor, and cardiovascular disease prevention effects.
Acerola: Acerola fruit is one of the natural resources with the highest L-ascorbic acid content, and L-ascorbic acid is the most biologically active configuration among the four isomers of Vc. L-ascorbic acid participates in a variety of biochemical reactions in the human body and has important clinical applications in maintaining cell integrity, increasing resistance, and preventing infection.
Mulberry fruit powder: Mulberry polysaccharide is the most important bioactive substance in mulberries, and has various physiological activities such as anti-tumor, antioxidant, antibacterial, hypoglycemic, hypolipidemic, and immune regulation.
Articles & Patents
[1]《Cancer statistics, 2023》
[2]《Study reveals how diet and probiotics boost melanoma immunotherapy response.》
[3]《Probiotic Gastrointestinal Transit and Colonization After Oral Administration: A Long Journey》
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