Probiotic composition with asthma improving effect and preparation method thereof
Patents no.: CN111991428A
Asthma is generally considered to be a body injury caused by excessive immune response of human body, and immune T cells of human body are classified into helper T cells (Th2) and regulatory T cells (Treg). Th2 cells can activate other immune cells capable of generating direct immune response; the regulatory Treg cells are responsible for regulating the immune response of the organism, play an important role in maintaining self tolerance and avoiding the excessive damage of the immune response to the organism, and are coordinated with each other to maintain the immune balance of the human body. However, after the asthma patient is exposed to the allergen, Th2 cells are increased and overactive, so that the IgE antibody of the immunoglobulin is released in a large amount; the suppression of regulatory Treg cells leads to a runaway immune response.
Short Chain Fatty Acids (SCFAs), an important metabolite of the intestinal flora, can play a role in maintaining immune balance. Research shows that short-chain fatty acids generated by the intestinal flora in decomposing dietary fibers can promote the generation of immune cells such as monocytes, and the monocytes migrate to the lung to become dendritic cells capable of inhibiting the differentiation of primary T cells into Th2 cells; meanwhile, the formation of T regulatory (Treg) cells can be promoted, so that the number of Th2 cells can be inhibited, the immune balance of a human body can be maintained, and the effect of improving asthma can be achieved.
The human body oral administration probiotics can regulate intestinal flora, and
Short Chain Fatty Acids (SCFAs) which are important metabolites of the intestinal flora can play a role in maintaining immune balance. Research shows that short-chain fatty acids generated by the intestinal flora in decomposing dietary fibers can promote the generation of immune cells such as monocytes, and the monocytes migrate to the lung to become dendritic cells capable of inhibiting the differentiation of primary T cells into Th2 cells; meanwhile, the formation of T regulatory (Treg) cells can be promoted, so that the number of Th2 cells can be inhibited, the immune balance of a human body can be maintained, and the effect of improving asthma can be achieved.
The effect of oral administration of probiotics to human beings in improving asthma depends on the colonization ability of oral probiotics in the intestinal tract of human beings and the ability to inhibit harmful bacteria in the intestinal tract.
The invention provides a probiotic composition with an asthma improving effect, which can colonize in human intestinal tracts for a long time and has a good asthma improving effect.
The invention also provides a preparation method of the probiotic composition with the effect of improving asthma.
The probiotic composition with the function of improving asthma adopts the following technical scheme: a probiotic composition with an asthma improving effect, which comprises Lactobacillus johnsonii LBJ 456, Lactobacillus rhamnosus PB-LR76 and Bifidobacterium lactis HH-BA68, wherein the Lactobacillus johnsonii LBJ 456 has a preservation number of CCTCC NO: m20191013, wherein the preservation number of the lactobacillus rhamnosus PB-LR76 is CCTCC NO: m2018887.
The invention has the beneficial effects that: the probiotic composition can colonize in human intestinal tracts for a long time, has a good inhibition effect on harmful bacteria such as salmonella enteritidis, escherichia coli, enterococcus faecalis, salmonella typhimurium and the like, and can effectively improve asthma.
The probiotic composition with asthma improving effect of the invention can play the following roles: the composition can stimulate the receptors on dendritic cells on the intestinal canal wall, combine with the receptors, activate and activate the translation proteins in the cells to move into the nucleus to release a large amount of cytokines, and promote the secretion of interleukin 12(IL-12) and interferon gamma to be increased, thereby effectively improving the asthma symptom. Secondly, the probiotic composition with the asthma improving effect can prevent and improve asthma, mainly by passing and balancing a micro-ecosystem of an intestinal tract, and inducing Th1 cell reaction by stimulating an intestinal tract immune system, so as to improve asthma; the asthma caused by excessive Th2 type immune response is improved by regulating Th1 type immune response to inhibit immunoglobulin IgE. ③ the probiotic composition with asthma improving effect of the invention comprises one or more probiotic strains, and the effect of preventing and improving asthma is strong and weak, depending on the selected functional probiotic strains.
The probiotic composition with the asthma improving effect provided by the invention is used for improving asthma, and the asthma improving effect can reach more than 60%.