No, Lactobacillus plantarumis generally considered a low-histamine or histamine-neutral probiotic strain.
Key points about Lactobacillus plantarum and histamine:
- Lactobacillus plantarum does not produce histamine: Unlike other probiotics (e.g., L. casei, L. reuteri), L. plantarum does not generally carry the gene for histidine decarboxylase, an enzyme that converts histidine into histamine.
- Research suggests L. plantarum helps degrade histamine: It can break down histamine in the human gut, which is a potential benefit for people with histamine intolerance.
- Often recommended for histamine intolerance: Many low-histamine probiotic blends contain L. plantarum because of its safety and potential antihistamine effects.
If you have histamine intolerance:
- You can safely try it: L. plantarum is unlikely to worsen symptoms.
- Further review of other strains: If taking a multi-strain probiotic, make sure there are no high histamine producers.
- Be aware of food sources: Fermented foods such as sauerkraut may contain other histamine-producing microorganisms, so supplements are safer.
Would you like recommendations for a specific low-histamine probiotic brand? Feel free to contact us!





