Specific protein Akkermansia muciniphila is still effective after inactivation The researchers isolated a protein called Amuc_1100 from the outer membrane of akkermansia probiotic bacteria, which remains active after heating to 70°C. Let me explain here, that inactivated akkermansia muciniphila probiotic bacteria use special inactivation technology to resist environmental influences, but retain the original structure and characteristics of beneficial bacteria. The inactivation technology avoids risks such as live bacterial infection, and researchers speculate that this makes the inactivation of Akk probiotic bacteria more effective.
Experiments on mice have shown that supplementation with akkermansia probiotic (whether live or inactivated) can effectively improve symptoms such as obesity, type 2 and type 1 diabetes, hepatic steatosis, intestinal inflammation, and different cancers (such as colon cancer, response to immune checkpoints) in mice.
Other studies have shown that mice taking live or inactivatedAkkermansia muciniphila postbiotics daily can reverse metabolic disorders caused by a high-fat diet, including fat gain, metabolic endotoxins, adipose tissue inflammation, and insulin resistance.
A study published in Nature Medicine conducted clinical trials using AKK probiotics bacteria, and the results showed that inactivated AKK bacteria can effectively prevent the deterioration of the condition of patients with prediabetes and critical cardiovascular disease, while also reducing lung inflammation and slightly reducing body weight and cholesterol levels.
AKK probiotics bacteria have great advantages in the research and development of new probiotic products due to their stable colonization, wide range of therapeutic effects, efficacy after inactivation, and high commercial value.
At present, some companies have screened out Akkermansia muciniphila from healthy human intestines and have achieved industrial production. It has a wide range of applications and has been developed into probiotic dietary supplements such as capsules and tablets abroad.
Source: In July 2019, "Nature Medicine" published a clinical trial of Akkermansia intervention from the team of Patrice D Cani of the University of Leuven in Belgium. The study included 32 overweight/obese volunteers with insulin resistance for a randomized, double-blind, placebo-controlled experiment. The results show that supplementing inactivated Akkermansia bacteria can significantly improve multiple metabolic indicators of overweight/obese insulin-resistant patients and increase the patients' insulin sensitivity by about 30%!
