How Probiotics Help You Sleep Better?
The gut-brain axis refers to the bidirectional communication between the gastrointestinal tract and the brain through neurotransmitters produced by cells and metabolites produced by the microbiota in the gut. Clinical, epidemiological, and immunological evidence suggest that the gut microbiota not only regulates the function and health of the human gut, but also extensively and profoundly influences the gut-brain relationship. For example, several mood disorders, such as anxiety, depression, and autism spectrum disorders now have well-established links to functional GI disruptions and microbiota dysbiosis. What’s more, it may play an important role in the etiology and pathogenesis of sleep disorders.
As we know, sleep is a complex physiological process and is a critical determinant of physical and mental health. There is a growing prevalence of sleep problems and insomnia worldwide, urging the development of new treatments to tackle this increase. Several studies have suggested that the microbiota-gut-brain axis contributes to the regulation of sleep behavior both directly and indirectly. The gut microbiota affects the host’s health via the production of metabolites and compound, which include short chain fatty acids, secondary bile acids and neurotransmitters. Some of them are independently known as sleep-promoting, such as gamma-aminobutyric acid(GABA) and melatonin.
GABA is a non-protein amino acid that can be found in a wide range of microbes, plants, and mammals. It is involved in brain metabolism, memory formation, cognition, and sleep. Lactic acid bacteria have widely been reported as a GABA producer and are safe for human consumption. Lactobacillus, Enterococcus, Leuconostoc, Pediococcus, Propionibacterim, and Weissella are among the most common and significant GABA-producing bacteria. In terms of microbial species, either the putrescine or glutamate decarboxylase pathways can be used to biosynthesise GABA.
Besides, probiotics can help improve sleep by reducing inflammation and promoting a healthy gut microbiome. Probiotics may also increase serotonin levels, which is an important neurotransmitter in sleep regulation.
Sleeping Support Probiotics
Ingredients
Lactobacillus acidophilus HH-LA26, Lactobacillus plantarum HH-LP56, Bifidobacterium lactis HH-BA68, Lactobacillus casei PB-LC39, Gamma-Aminobutyric acid, valerian extract, melatonin
Characteristics
1. Trail-blazing probiotic formulated with other functional ingredients, to help deal with occasional sleeplessness, but can also help support feeling of relaxation and reduced tension
2. These doctor-formulated probiotics are suitable for both men and women and have been shown to help promote intestinal comfort, balance gut microbiota and show positive effects on gut-brain axis.
3. Non-habit forming, drug free, all natural ingredients.
4. Helpful for individuals, jet lag, or unusual work shifts.