Gut-liver axis：
The gut-liver axis refers to the bidirectional relationship between the gut and its microbiota, and the liver, resulting from the integration of signals generated by dietary, genetic and environmental factors. This reciprocal interaction is established through the vascular route of the portal vein that carries gut-derived products directly to the liver, and the liver feed-back route of bile and antibody secretion to the intestine. The intestinal mucosal and vascular barrier is the functional and anatomical structure that serves as a playground for the interactions between the gut and the liver, limiting the systemic dissemination of microbes and toxins while allowing nutrients to access the circulation and to reach the liver.
Alcohol metabolism：
Most of the alcohol consumed is metabolized in the liver by alcohol dehydrogenase(ADH), which catalyzes the oxidation of alcohol to acetaldehyde, and by aldehyde dehydrogenase(ALDH), which
metabolizes acetaldehyde to form acetic acid. The acetaldehyde produced during the oxidation process accumulates, rather than alcohol itself, and causes liver cell damage and hangover.
Cholestasis：
Cholestasis is a pathological state in which bile synthesis, secretion, and excretion are impaired, rendering bile unable to carry out normal liver intestinal circulation. The accumulation of bile exceeds the limits of normal liver cells, resulting in cell injury to the liver parenchyma, toxic damage to the biliary tree, and subsequent obstruction of bile inflow or outflow.
Proven Efficacy
Probiotic Strains：
L.casei PB-LC39
Origin: isolated from traditional fermented milk in Qinghai Province.
Culture Deposit Number: CCTCC M2018886
L.helveticus HH-LPH17
Origin: isolated from traditional dairy product
Culture Deposit Number: CCTCC M2021725
Reduce alcohol-related liver damage：
Alcohol metabolism capacity of some probiotic strains were evaluated in vitro by inoculating bacterial suspesion into alcohol solution and measuring the residual alcohol concentrations after
incubation. Among the tested probiotic strains, L.casei PB-LC39 showed high capacity for alcohol metabolism, indicating its potential to protect against alcohol-induced liver damage.
In hyperammonemic mice, PB-LC39 showed great capacity in reducing serum blood ammonia level, resulting in lower risk of liver damage caused by ammonia.
Improve cholestatic liver disease：
In animal study, L.helveticus HH-LPH17 showed to prevent accumulation of bile acids in the liver and controlled ALT and AST levels in blood.
Patent：
A L.casei-containing probiotic formula for alcohol metabolism and detoxification, the preparation method and application thereof. (Patent No.:ZL.201910895017.0)
L.helveticus strain capable of being used for preventing and treating cholestatic liver diseases and application thereof (Patent No.:ZL.202111288184.2)
Liver Health Probiotics：
Supplement Facts
Serving Size: 1 vegetarian capsule
Servings Per Container: 60
Amount Per Serving %DV *
Probiotic Blend 30 Billion CFU +
Lacticaseibacillus casei PB-LC39
Lactobacillus helveticus HH-LPH17
Lactiplantibacillus plantarum HH-LP56
Lactobacillus acidophilus HH-LA26
*Daily Value(DV) not established
Other Ingredients: stachyose, Ampelopsis grossedentata leaves powder, amomi fructus extract, corn oligopeptides powder, apple cider vinegar powder, inulin, microcrystalline cellulose, multi-
vitamins, taurine, magnesium stearate, silica.
Improves alcohol metabolism.
Aids Natural Liver Detoxification.
Formulated with Chinese herbal extracts to support gastrointestinal health.
Directions: For best results, take one capsule per day for at least two weeks.
Maintain urogenital health
Improves digestive system
Directions: For best results, take one capsule per day for at least two weeks.
Consumer Study：
In the consumer study, 45 adults(men and women) between the age 35 to 55 years were recruited to the study and asked to consume the Liver Health Probiotic capsule once daily for 21 days and send the filled questionnaire. The table below demonstrates the improvement of discomfort in the participants.
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