PRODUCT DESCRIPTION

Heat-Treated Probiotics is a kind of paraprobiotics, defined as “inactivated microbial cells (non-viable) that confer a health benefit to the consumer,” hold the ability to regulate the adaptive and innate immune systems, exhibit anti-inflammatory, antiproliferative and antioxidant properties and exert antagonistic effect against pathogens. Moreover, heat-treated probiotics can exhibit enhanced safety, assure technological and practical benefits and can also be used in products suitable for people with weak immunity and the elderly. ”

SPECIFICAITON

Product Name	Heat-treated probiotics	Code	-
Potency	100bn cells/g	Gene Identification	Yes
Deposit	CCTCC	Certification	ISO,HACCP,HALAL,KOSHER
Packing	500g,1kg or 5kg per foil bag	Storage	-18℃ for long time, 2-8℃ for short time

TECHNICAL INDICATORS

ADVANTAGES OF HEAT-KILLED PROBIOTICS

1. Safety
For people with low immunity or immune deficiency, taking live bacteria preparation has potential harm. Once the bacteria mutate
or transfer drug resistance gene to pathogens, it may induce diseases. Therefore, inactivated probiotics have higher safety.

2. Stress resistance
In order to confer health benefits to the host, probiotics should be resistant to stomach acid, bile and various digestive
enzymes, all of which have the effect of killing live probiotics. Inactivated probiotics cells are not affected by environmental
changes and are resistant to high temperature, gastric acid, bile and alkali, so they are easier to transport and store and have
high quality stability.

3. Use with antibiotics
Antibiotics not only kill pathogenic bacteria, but also kill probiotics, resulting in dysbacteriosis. Inactivated probiotics are
not live bacteria, so antibiotics can not cause damage to them.

4. High processability
The high stress resistance and stability of inactivated probiotics enable them to be added in almost all kinds of food and
medicine, especially in some foods and drugs with low water content and heated treatment.

HEALTH BENEFITS

1. Immune modulation
Lipoteichoic acid (LTA) is a major component of the cell wall of Gram-positive bacteria and is released from bacterial cells by lysozyme, leukocyte cationic polypeptide or antibiotic induced lysozyme. It has been found that LTA can significantly promote the mitosis of T cells and stimulate lymphocytes. In addition, LTA can also adhere to and activate monocytes and macrophages, and induce the production of a variety of cytokines. It was confirmed that LTA of heat-killed probiotics had strong immune induction ability compared with live probiotics.

2. Inhibit pathogenic microorganisms
The ability of heat-killed probiotics to inhibit pathogenic bacteria mainly result from their ability to enhance body's immunity, competition for space during bacterial colonization, direct inhibition ability of metabolites and cell lysates to pathogenic microorganisms.

3. Allergy relief
Heat-killed probiotics can alleviate allergic symptoms by modulating Th1/Th2 responses toward a Th1-dominant state.

STORAGE REQUIREMENTS

Storage at well closed condition.
Shelf life: 24 months at room temperature