Probiotic therapy in Helicobacter pylori infection
Helicobacter pylori is a common type of bacteria that grows in the digestive tract and tends to attack the stomach lining. Helicobacter pylori infection occurs when H.pylori bacteria infect your stomach. H.pylori bacteria are usually passed from person to person through direct contact with saliva, vomit or stool. H.pylori may also be spread through contaminated food or water. Worldwide, around 44% population have been infected by H.pylori.
H.pylori infection is usually harmless, however, it is associated with many complications, such as ulcers, inflammation of stomach lining, and even stomach cancer. For the prevention of H.pylori associated complications, inhibition of infection is in the first priority. The treatment of HP infection includes a pair of antibiotics with proton pump inhibitor PPI. However, increasing incidence of resistant H.pylori strains to antibiotics reduces the effectiveness of antibiotic therapy. Moreover, antibiotics may also show some side effects such as diarrhea, nausea, and gut dysbiosis. Therefore, seeking for a safer and more efficient approach is urgently needed.
Probiotics have been extensively researched as an adjunct or alternative approach to antibiotics treatment for H.pylori infection. Numerous studies related to the antagonistic activity of probiotics against H.pylori have shown promising results in reducing antibiotic side effects, improving eradication of H.pylori infection and reducing cell injury.
Probiotic’s antagonistic effect on H.pylori
Strengthening mucosal barrier
Probiotics protect the mucosal barrier from damage by modification of the relevant gene or protein expression and the increased production of IgA
Competition for adhesion
Some probiotic strains can prevent H.pylori from binding to the epithelial cells by competing for the adhesion sites or nutrients, causing steric hindrance and secreting antimicrobial substances
Secretion of antimicrobials
Probiotics can secrete lactic acid, which can lower down the surrounding pH making it unfavorable for H.pylori growth and inhibit urease’ activity. Besides, bacteriocin-mediated inhibition of H.pylori has been studied.
Immunomodulation mechanism
Probiotics can interact with gastric epithelial cells and reduce the inflammation caused by H.pylori infection.
Anti-H.Pylori Probiotic Supplement
Ingredients
inulin, galactooligosaccharide, stachyose, sea buckthorn powder, Ericius erinaceus extract, maltodextrin, L.reuteri PB-LR09, L.johnsonii LBJ456, L.plantarum HH-LP78, L.salivarius HH-LS17, L.casei PB-LC39, L.acidophilus HH-LA26, B.bifidum HH-BB27, B.breve HH-BR26
Characteristics
The natural treatment for Helicobacter pylori. Contains probiotics and functional plant extracts.
Relieves acid lifts, stomach aches and pain, ulcers and chronic gastric discomfort
Improves digestion and boosts the immune system
