Probiotics can inhibit the growth of pathogenic bacteria by producing organic acids, reducing intestinal pH, competing for nutrients, occupying space, and producing bacteriocins, maintaining the inherent intestinal flora and maintaining the balance of intestinal flora, thereby further regulating the body's immune function. details as follows:
1. The regulatory effect of probiotics on non-specific immune function
Strengthen the intestinal mucosal barrier: Probiotics can not only stimulate the growth of indigenous bacteria in the intestine, but also inhibit the growth, adhesion and invasion of pathogenic bacteria through various ways, normalize the imbalanced flora, thereby enhancing intestinal biology. barrier function. At the same time, probiotics can compete with harmful bacteria for nutrients and inhibit their growth.
Enhance immune cell activity: Phagocytes include various macrophages, monocytes, etc. Daily intake of small amounts of probiotics can enhance the effects of macrophages and other non-specific immune responses.
2. The regulatory effect of probiotics on humoral immunity
A large number of studies have shown that probiotics can stimulate the proliferation of human sIgA-secreting cells, thereby increasing sIgA levels. sIgA is a very important antibody molecule that plays a decisive role in the body's first line of defense against disease. sIgA is considered to be the immune barrier on the mucosal surface. It can effectively inhibit the adhesion, colonization or invasion of the mucosal surface by pathogens. This immune exclusion function can protect the integrity of the mucosal barrier and block the infection of the body by pathogens.
3. Effect of probiotics on cellular immunity
The effects of probiotics on the body's cellular immunity mainly include activating macrophages, B lymphocytes and NK cells, and promoting the production of cytokines such as interleukin (IL) and interferon (IFN).
4. Probiotics form a bacterial film barrier in the intestines
Probiotics adhere to the surface of the intestinal mucosa, forming a bacterial membrane barrier. A large number of probiotics and pathogenic bacteria seize the attachment position and common fermentation substrate in the intestine, and secrete substances with bactericidal activity to directly eliminate harmful bacteria or other After potential adhesion, harmful bacteria are taken out of the body through feces and other methods, so that harmful bacteria cannot survive in the intestines.